string(17) "en/about/691.html" Embryo Technology Platform-Shenzhen Medical Academy of Research and Translation
Home Animal Experimentation Center

Specialized Services

Embryo Technology Platform

　　The Embryo Technology Platform is equipped with advanced instruments, including stereomicroscopes, CO2 incubators, needle pullers, microforges, microinjectors, electroporators, and inverted fluorescence microscopes, and staffed by professional technical personnel. The platform offers comprehensive professional technical services covering biocleaning (bio-rederivation), rapid colony expansion, sperm cryopreservation and recovery (resuscitation), embryo cryopreservation and recovery, generation of genetically modified mice, breeding of core colonies, and breeding of genetically modified mice. It provides one-stop services for mouse embryo manipulation, such as in vitro fertilization (IVF), microinjection, and embryo transfer. Currently, the platform has a team of 4 members, including one Ph.D. and three bachelor’s degree holders.


Talent Pool

Zheng Guoxing

Zheng Guoxing

Director, Embryo Technology Platform

Education and Research Experience

2007–2011: Ph.D. in Biomedical Sciences, Texas A&M University, USA. Investigated the regulatory role of SRF-directed microRNAs in cardiac development.

2011–2013: Postdoctoral Fellow, The University of Texas MD Anderson Cancer Center, USA.

2013–2018: Postdoctoral Fellow, School of Medicine, Tsinghua University. Conducted mechanistic studies on arrhythmogenic right ventricular cardiomyopathy (ARVC) and autoimmune diseases.

2018–2023: Assistant Research Fellow, Scientific Research Center, and Teaching Secretary, Department of Basic Medical Sciences, The Seventh Affiliated Hospital of Sun Yat-sen University. Research focused on tumor immunology and hematological disorders.

2023.04–present: Joined the Animal Experimental Center of Shenzhen Medical Academy of Research and Translation (SMART) as Director of the Embryo Technology Platform.


Expertise and Responsibilities

Provide consultation, model generation, and technology development services for a wide range of animal genetic models, including transgenic, knockout, and knock-in models, with a particular focus on Cas9-mediated gene editing. Dedicated to applying and optimizing CRISPR/Cas9 technology to rapidly, efficiently, and cost-effectively generate gene-edited mice — including gene knockout, gene mutation, and transgenic mouse models — to recapitulate the onset, progression, and treatment of various human diseases, thereby establishing disease animal models for pathological and pharmacological research. Coordinate and oversee the daily operations of the Embryo Technology Platform, including genetic resource preservation such as bioreduction/cleaning, sperm cryopreservation and recovery, embryo cryopreservation and recovery, and rapid colony expansion.

Research Funding

Principal Investigator for one project each funded by the China Postdoctoral Science Foundation and the Shenzhen Municipal Science and Technology Innovation Commission. Participated in six projects funded by the National Natural Science Foundation of China and provincial-level grants.

Publications

Published 16 SCI-indexed papers in journals including Nature Immunology, Immunity, Protein & Cell, and Frontiers in Immunology. Among these, one paper with an impact factor (IF) >10, and three papers with an IF >20. Served as first author or corresponding author on six SCI publications.

Selected Publications


Guo Feng

Guo Feng

Animal Experiment Engineer

A bachelor’s degree from Inner Mongolia University of Science and Technology was earned, and work has since been focused on mouse biopurification, assisted reproduction, rapid expansion, embryo transfer, and experimental operations of sperm/embryo cryopreservation and resuscitation. Participation in related technical services has also been undertaken.


Ting Liu

Ting Liu

B.S. in Clinical Medicine, Shaoyang University

B.S. in Clinical Medicine, Shaoyang University. Provide full-pipeline mouse embryo manipulation services, offering stable, efficient, and traceable generation of genetically modified mouse models and platform support for research projects. Dedicated to the design and construction of Cas9-mediated gene editing, as well as the application of microinjection, in vitro fertilization (IVF), embryo transfer, biocleaning, cryopreservation and revival of sperm and embryos, and rapid expansion.

Jiaquan Luo

Jiaquan Luo

Animal Experiment Engineer

A bachelor’s degree from Guangdong Ocean University was earned, and work has since been focused on generating genetically modified animals through techniques such as microinjection, electroporation, ES cell targeting, biopurification, and IVF‑ET propagation. Technical services including sperm and embryo cryopreservation as well as the breeding of genetically engineered animals have also been undertaken.


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