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Welcome to SMART Core Facility
In modern biomedical research, the breeding and management of laboratory animals is not only labor-intensive but also technically demanding. To help researchers address challenges such as manpower shortages and low breeding efficiency, we offer specialized, customized agent breeding services. Based on the specific needs of researchers, we perform standardized natural breeding and strain maintenance, develop personalized breeding strategies aligned with breeding goals, and ensure precise genetic management and process control. Ultimately, we deliver laboratory animals of specified quantities, genotypes, and ages as required. We have established two full-process technical capabilities, as listed below (Table 4.1).
Table 4.1 Full-Process Agent Breeding Service List
No. | Service Item | Technical Description |
1 | Agent Breeding (Natural Breeding) | Utilizing scientifically optimized natural breeding strategies, we strictly establish pedigree-based mating according to the inbred and outbred backgrounds of laboratory animals. This approach maximizes the preservation of the animals' physiological functions and genetic integrity while coordinating with researchers' experimental timelines to ensure animals are delivered at the optimal age. |
2 | Live Colony Maintenance | Live colony maintenance employs a small core population (5 males and 5 females, with the number of cages kept within 6). Breeder replacement is conducted approximately every three months by introducing backup breeders to prevent inbreeding depression and colony aging, ensuring long-term genetic stability and controlled health status. |
Our platform currently provides agent breeding services for three research groups within the institution, covering a total of four strains, with continuous batch deliveries of offspring animals.
Key technologies under recent development:
1. Integration of cryopreservation with live colony maintenance;
2. Intelligent system management;
3. Combination of natural breeding with rapid expansion through assisted reproduction et al.